Core technology for mRNA vaccines & therapeutics
- 15’ capping (SMARTCAP®)
- 2LNP Platform
CDMO
mRNA
ST PHARM's mRNA CDMO Core Strength
The Limitless Future of xRNA Therapeutics
Established IVT-based mRNA-LNP CDMO platform
- 1mRNA Platform (5’ capping & LNP)
- 2GMP Production Site (Banwol Campus)
ST PHARM's mRNA Core technology
SMARTCAP®
Strong IP position of ST PHARM's SMARTCAP®
using novel capping analogues.
mRNA
UTR
Coding Sequence
UTR
Capping
( SMARTCAP® )
ST PHARM's LNP Platform
ST PHARM is running 3 different LNP Platform strategies
- 1In-licensing LNP
- 2ST PHARM LNP (STLNP™)
- 3Next generation LNP (SMARTLNP™)
mRNA-LNP
Helper lipid
lonizable lipid
Cholesterol
Lipid-anchored PEG
mRNA
SMARTCAP®
- Cost-effective
- Novel capping analogues
- Various differrent types
SMARTCAP® Library
- Customized capping choice
- Apply in various targets
- Identify the best capping
(high capping efficiency)
STLNP™
- Platform for CDMO
- Own patented
- Advanced delivery system
ST Pharm's mRNA CDMO Service
ST PHARM's IVT-based mRNA-LNP CDMO Platform
New 5’ Capping Analogue
- Novel ST PHARM's own cap analogues, SmartCap®
- Capping library screening to select the most suitable capping analogue
IVT mRNA Synthesis
- Ample know-hows in mRNA optimazation in IVT-based mRNA synthesis & codon optimization
Drug Delivery System (LNP)
- Lipid-Nanoparticle (LNP) based mRNA delivery platforms with diverse collaborations with champions in the field
Purification
- Leveraging in-house ample experience on oligonucleotide purification method using UF and HPLC
- One-pot purification system
GMP Manufacturing
- Strong track record of nucleotide/ oligonucleotide GMP manufacturer
- All steps controlled under GMP conditions
CMC & Regulatory
- Analytical and biophysical characterization & analytical method development
- Regulatory SOP & guideline preparation
Capacity (Banwol Campus)
ST PHARM is highly dedicated to innovative, continuous improvement
and expanding mRNA facility
mRNA Plant
Capacity
Site
Note
Stage 1. (Aug. 2020)
R&D and small scale
(milligram/month)
(milligram/month)
mRNA Plant (1F)
Non-GMP
Stage 2. (May. 2021)
Mid-scale
(multi-gram/month)
(multi-gram/month)
mRNA Plant (1F & 4F)
GMP
Stage 3. (Planned)
Large-scale
(1.0kg/annum)
(1.0kg/annum)
mRNA Plant (3F & 5F)
GMP
Banwol Campus
mRNA Plant